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Cell Line Name：                    

EGFR D770_N771insY/BaF3                    

Host Cell:                    

Ba/F3                    

Application:                    

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.                    

Freeze Medium:                    

Complete Culture Medium:                    

Mycoplasma Status:                    

Negative                    

EGFR D770_N771insY results in the insertion of a tyrosine (Y) in the protein kinase domain of the Egfr protein between amino acids 770 and 771 (UniProt.org). D770_N771insY has not been biochemically characterized, but is predicted to result in a gain of function based on the effect of other Egfr exon 20 insertions (PMID: 24353160).                    

1. WB of EGFR D770_N771insY/BaF3